Anti-atherosclerotic action of GW9508 – Free fatty acid receptors activator – In apoE-knockout mice

BackgroundIn the past two decades, enhanced understanding of the biology of G-protein-coupled receptors (GPRs) has led to the identification of several such receptors as novel targets for free fatty acids (FFAs). Two GPRs, FFAR1 and FFAR4, have received special attention in the context of chronic inflammatory diseases, thanks to their anti-inflammatory activities.MethodsThe present study investigates the influence of prolonged treatment with GW9508 – agonist of FFAR1 and FFAR4 – on the development of atherosclerosis plaque in apoE-knockout mice, using morphometric and molecular methods.ResultsGW9508 administration has led to the reduction of atheroscletoric plaque size in an apoE-knockout mice model. Moreover, a FFAR1/FFAR4 agonist reduced the content of macrophages by almost 20%, attributed by immunohistochemical phenotyping to the pro-inflammatory M1-like activation state macrophages.ConclusionsProlonged administration of GW9508 resulted in significant amelioration of atherogenesis, providing evidence that the strategy based on macrophage phenotype switching toward an M2-like activation state via stimulation of FFAR1/FFAR4 receptors holds promise for a new approach to the prevention or treatment of atherosclerosis.     

布地奈德联合博利康尼治疗慢性阻塞性肺疾病急性加重期疗效分析

目的观察布地奈德联合博利康尼治疗慢性阻塞性肺疾病急性加重期的临床疗效。方法选择2017年12月~2018年12月我院住院治疗的慢性阻塞性肺疾病患者80例,随机分为观察组和对照组,各40例,对照组予布地奈德雾化液1 mg+生理盐水3 m L,每天2次雾化吸入;观察组在对照组基础上加用博利康尼雾化液l mg联合布地奈德雾化液1 mg+生理盐水3 m L雾化吸入,每天2次,6 d为一个疗程。治疗后对比分析两组的临床疗效及肺功能各项指标的变化情况。结果观察组患者治疗后的总有效率达97.2%,显著高于对照组的75.0%,两组比较差异具有显著性(P0.05)。观察组患者治疗后的FEV1、PEF及FEV1/FVC分别为(1.93±0.27)L,(3.81±1.16)L/s、(90.43±12.65),均较治疗前明显提高,且观察组患者治疗后的FEV1、PEF及FEV1/FVC水平分别显著高于对照组,两组比较差异具有显著性(P0.05)。结论布地奈德联合博利康尼治疗慢性阻塞性肺疾病急性加重期疗效确切,能明显改善患者的肺功能,从而缓解患者的临床症状,提高生活质量,改善预后。     

长沙市新型冠状病毒肺炎流行特征分析

目的 了解长沙市新型冠状病毒肺炎(coronavirus disease 2019,COVID-19)流行特征,为疫情防控提供依据。方法 采用描述流行病学方法对长沙市2020年1月1日—3月6日期间的新型冠状病毒肺炎流行特征进行分析。结果 2020年1月1日—3月6日期间长沙市累计报告新型冠状病毒肺炎确诊病例242例,重症率15.70%;长沙市每日报告确诊病例数自2月3日以来整体呈下降趋势。209例出院病例的住院天数为5~37 d,平均住院天数为(16.91±7.32)d;发病以30~50岁年龄组为主(23.95%),50岁以上人群的重症率最高(26.26%, χ²=14.124,P=0.001),职业以家务及待业(16.53%)和离退人员(15.70%)为主;主要临床表现为发热(65.70%)、干咳(41.74%)和乏力(33.06%)。结论 新型冠状病毒肺炎发病数虽呈下降趋势,但随着人员流动的增加,需加强防控措施防止疫情反弹。     

Intraventricular entrapment of a Sapien-3 balloon in transapical TAVR: A near missed catastrophe

Balloon rupture is an uncommon complication during balloon-expandable transcatheter aortic valve replacement (TAVR). We describe a balloon rupture and tearing with intraventricular entrapment complicating transapical-TAVR, as well as our bailout retrieval of the failed device.